CuSkin Mixtape

Copper Peptides for Men: The Complete Topical Guide

Last checked October 4, 2026

Welcome! Copper peptides are skincare ingredients you put on your skin, usually in a serum. This guide covers how to use them in a simple men’s routine and what to keep them away from.

Want a plan for the products you already own? Give the Routine Builder a spin.

What are copper peptides?

The copper peptide in serums like The Ordinary’s is GHK-Cu. It is a small peptide bound to copper, and it is listed on labels as copper tripeptide-1.

Quick note: this site covers topical products only. We don’t cover injectable GHK-Cu, “research peptides,” or dosing.

What can they do for skin?

Here’s the scoop. In small studies, copper peptide creams made skin look firmer and smoother, with fewer visible fine lines. The studies were small and short, so the evidence is limited.

Those studies come from a review by Loren Pickart, who first isolated GHK and founded companies that sold copper peptide products.

How to use copper peptides

  • Time of day: Morning or night both work. Night is a simple default.
  • Order: Thinnest to thickest. Serums go before moisturizer.
  • Sunscreen: Always the last step in the morning.
  • New product: Patch test on a small area first.

A basic routine looks something like this:

Morning Night
Moisturizer Copper peptide serum
Sunscreen Moisturizer

How often: Follow your product’s directions. The Ordinary says its copper peptide serum can be used morning and evening. If you use other actives, the Routine Builder shows when to fit it in.

What not to mix

Keep copper peptides apart from vitamin C, retinoids, exfoliating acids, and benzoyl peroxide. Niacinamide, hyaluronic acid, and other peptides are fine together. Read the full list in what not to mix with copper peptides.

After shaving

We found no guidance on copper peptides after shaving specifically. If your skin is irritated after shaving, skip skincare actives like copper peptides, acids and vitamin C until it calms down, and use a simple moisturizer. Keep using any prescription or acne treatment as directed, and ask your doctor if the irritation doesn’t settle. See copper peptides after shaving.

If something goes wrong

Stop the product if your skin reacts. See a dermatologist or doctor if it lasts. Read troubleshooting for common setup problems.

Pregnancy, prescriptions, and skin conditions

Ask your doctor before using copper peptides if you are pregnant or breastfeeding, use a prescription skin product, or have a skin condition.

Where this comes from

Facts on this page link to their sources, so you can click through and check our work. Curious how we pick sources? Here's How We Do Our Homework.

Frequently asked questions

Should I use copper peptides in the morning or at night?

Either works. Night is a simple default. If you use vitamin C in the morning, keep copper peptides at night.

Do copper peptides go before or after moisturizer?

Before. Serums go on before moisturizer. Thinner products go on first.

Does this site cover copper peptide injections?

No. This site covers topical products only. It does not cover injectable GHK-Cu or research peptides.